专利名称：Antisense design
发明人：Signe M. Christensen,Nikolaj Dam
Mikkelsen,Miriam Frieden,Henrik FrydenlundHansen,Troels Koch,Daniel Sejer
Pedersen,Christoph Rosenbohm,CharlotteAlbaek Thrue,Majken Westergaard
申请号：US15618650申请日：20170609公开号：US09890383B2公开日：20180213
专利附图：
摘要：A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA)which can be used in antisense therapy. These novel oligonucleotides have improvedantisense properties. The novel oligonucleotides are composed of at least one LNAselected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. Theoligonucleotides comprising LNA may also include DNA and/or RNA nucleotides.
申请人：Roche Innovation Center Copenhagen A/S
地址：Basel CH
国籍：CH
代理机构：Fish & Richardson P.C.
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